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KMID : 0613820060160071188
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Journal of Life Science
2006 Volume.16 No. 7 p.1188 ~ p.1194
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Bioinformatics Analysis of Gene Expression Regulation by Transposable Elements in Dementia Patients
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Kim Dae-Soo
Huh Jae-Won
Ha Hong-Seok
Kim Tae-Hong
Jo Un-Jong
Kim Heui-Soo
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Abstract
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Dementia is a progressive disease of increasing the dysfunction of intellectual and physical ability. In the aging society, many families are suffering from the caring the patients who are diagnosed with dementia. However, dementia is a complex disease affected by the genetic and environmental agents. In the present study, we investigated the transposable elements in relation to dementia. From the analysis of dementia EST (expressed sequence tag) sequences, we found dementia candidate genes, and analyzed expression profiles and repeat elements using bioinformatics tools. This analysis showed that 98 genes were affected in their mRNA sequences by transposable elements expression. Their expressions were affected by the integration of different transposable elements (SINE, LINE, LTR, DNA) during the primate evolution. We believe that our work will be of significant interest to genome scientists, and may help them gain insight into implication of transposable elements expression in dementia
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KEYWORD
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Dementia, EST, bioinformatics, transposable elements
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